Prophylactic Inhaled Beclomethasone Dipropionate in Infants <1250 grams for the Prevention of BPD † 1030

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The effects of inhaled beclomethasone dipropionate on lung function and histamine responsiveness in recurrently wheezy infants.

Inhaled steroids improve pulmonary function and bronchial responsiveness in older asthmatics. Data from studies using subjective outcome measures to determine the effectiveness of inhaled steroids in infants with recurrent wheezing are equivocal. Therefore, this study tested the hypothesis that beclomethasone dipropionate improves pulmonary function, including bronchial responsiveness to histam...

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Anti-inflammatory effects of inhaled beclomethasone dipropionate in nonatopic asthmatics.

The effects of inhaled beclomethasone dipropionate (BDP) on asthma symptoms and infiltration of the bronchial mucosa by inflammatory cells were investigated in an open study of 10 patients with mild-to-moderate nonatopic bronchial asthma. Asthma scores were recorded in an asthma diary. Peak expiratory flow (PEF), PEF diurnal variation (PEF%), forced expiratory volume in one second (FEV1%), meth...

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Effect of inhaled beclomethasone dipropionate on saliva cortisol concentrations.

Serial saliva cortisol measurements were used to assess pituitary-adrenal function in a group of asthmatic children treated with beclomethasone dipropionate (400 micrograms daily). Asthmatic children who were not being treated with steroids and normal children were also studied for comparison. A diurnal cortisol rhythm was observed in all three groups. Early morning cortisol concentrations were...

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Isolated cough which responds to inhaled salbutamol and beclomethasone dipropionate.

Within a year we have observed 19 patients (16 females) who presented to the Ear-Nose-Throat (ENT) department of our hospital for an isolated cough present from one month to 14 years duration. Their ENT medical examination was normal, except for one subject who complained of chronic rhinitis. They were normotensive and did not use an angiotensin converting enzyme inhibitor. In all of them bronc...

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Radiolabelling of Beclomethasone Dipropionate

Little is known about delivery of aerosolised steroids to neonatal patients undergoing assisted positive pressure ventilation and after extubation. A rabbit model has been established to investigate factors influencing drug delivery. Beclomethasone dipropionate, in a metered dose inhaler, was radiolabelied with technetium 99m. The mass median aerodynamic diameter of the aerosol was 3-3 (2.0) pm...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1998

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-199804001-01051